Abstract
Intra-arterial injection therapy with anticancer agent and lipiodol (LPD) suspension is recently performed in many cases, which is very useful for hepatocellular carcinoma. Cisplatin (CDDP) has been used in the treatment of hepatocellular carcinoma. However, its toxicity to kidney, blood and neuron are unsolved yet. We prepared CDDP-phosphatidylcholine (PC)-LPD suspension. Furthermore, we simultaneously tested suspensions composed of LPD with varying PC and CDDP contents. Various amounts of CDDP and PC were gradually mixed with 10 ml of LPD, respectively. The stability of these suspensions and size of these particles were affected by concentration of PC. Superior compositions of CDDP-PC-LPD suspensions were as follows : CDDP-PC-LPD : 50 mg-100 mg-10 ml and 100 mg-100 mg-10 ml. Nausea, vomiting and fever were noted in most cases as adverse effects, but they were slight. These results suggest that the intra-arterial injection therapy with CDDP-PC-LPD suspension can be an effective chemotherapy for the treatment of unresectable hepatocellular carcinoma.
