Abstract
Effects of strict glycemic control on insulin secretion and insulin action were studied in non-insulin dependent diabetics who had acute deterioration of glycemic control. Strict glycemic control was assessed with one-day operation of artificial endocrine pancreas followed by multiple insulin injections. Insulin doses for maintaining perfect daily glycemic control was comparble to these which was given before achievement of strict glycemic control. Oral glucose tolerance test showed an improvement in insulin secretion after strict glycemic control. Euglycemic hyperinsulinemic clamp test elucidated an recovery of insulin resistance after strict glycemic control. These results indicated that strict glycemic control could improve both insulin secretory ability and insulin sensitivity in acutely-deteriorated noninsulin dependent diabetics.
