Abstract
Blood flow of I-87 human lung carcinoma was measured using hydrogen clearance method. I-87 tumors were transplanted to the subcutis of nude rats(F344/Njcl). When the mean arterial blood pressure(BP)was elevated from 111.1±7.2 mmHg (mean±SD : normatension)to 155.7±5.9 mmHg (hypertension induced by angiotensin II : AII), blood flow of I-87 significantly induced from 8.2±4.9 ml/min/100 g to 38.2±30.7 ml/min 100 g(mean increse rate ; 6.3). A model of lung metastasis of rats (Donryu/Crj) was made by intravenous inoculation of AH100 (moderately sensitive to adriamycin) cells. Using these models in which metastatic foci of lung were histologically detected on day 3 after the inoculation, growth inhibitory effect were compared. In AH100b model, growth inhibitory effects were investigated by the ratio of area of tumor/ lung (%T/L) on photomontage of microscopicalsections. In day 10-samples of each treatment schedule, % T/L for AII induced hypertension chemotherapy (IHC), was significantly low comparing with that for non-IHC (P<0.05), and control (P<0.01). But in day 14-samples, there was no significant differences between groups because of regrowth of tumors. In a series of AH 100 B-bearing rats treated with adriamycin, no obvious prolongation of survival days was shown in all treatment groups. Under AII-IHC, chemoterapeutic effects on lung metastasis was augmented on the basis of selective increase of blood flow of lung carcinoma and enhancement of drug delivery to lung metastasis.
