Abstract
Peplomicin-containing poly (lactic acid)microspheres(PEP-MS)were prepared, and its long retention and lymphtropic delivery were studied. PEP-MS released 70% of PEP in saline within 24 hours. PEP and PEP-MS were injected into the esophageal wall of rabbits, and PEP concentration of peripheral venous blood and lymph of thoracic duct were measured from 5 minutes to 6 hours after injection. In group “PEP”, PEP concentration of peripheral venous blood and lymph of thoracic duct were same level, but in group “PEP-MS”, PEP concentration of lymph of thoracic duct was higher than of peripheral venous blood. One day after administration of PEP, PEP was not found in esophagus, lymph nodes, lung and kidney, But one day after administration of PEP-MS, PEP was found to still remain 3.0 μg/g in esophagus.
