Abstract
Directly injective chemotherapy combined with transcatheter arterial embolization (TAE) was achieved in 50 nodules with hepatocellular carcinoma. Four to thirty-five days after TAE, the anticancer agents dissolved in contrast media were directly injected into the tumor tissue using the ultrasonically-guided puncture needle. The dynamics of the anticancer drugs marked with non-ionic and water-soluble contrast media was explored by the sequential CT studies. The accumulation of the contrast media was obserbed in 27 out of 50 tumor nodules during 2 weekes or more after the injection. In one case, who was autopsied 6 months after the injection, the higher concentration of anticancer drugs and iodine in the tumor tissues was detected than in surrounding liver parenchyma. In conclusion, this procedure was considered to be an effective drug delivery method to achieve a targeting chemotherapy in the tumor nodules.
