Abstract
The immunological response in intratumor administrated anticancer polymer-composites were studied in the human malignant gliomas. Patients with glioblastoma and anaplastic astrocytoma were treated by local chemotherapy with 5Fu or ACNU polymer composites and radiotherapy, Surgical specimens of pretreated and posttreated with maligant glioma were investigated by immunohistochemistry using GFAP, Vim, LCA, UCHIL-1, L-26, EMA, Leu7, CR3/43, KP-1, and MAC-387. LCA and MAC 387 in pretreated glioma tissue were not seen. UCHL-1 and MCA-387 were infiltrated in the peritumorous region of posttreated glioma. The natural immunological response dose not work in the glioma tissue, but after local therapy, cellular response were increased in the peritumorous area of recurrent glioma
