Abstract
Cisplatin is an anticancer drug with broad-spec-trum, that is especially effective against genitourinary tumors. But it shows serious toxicity in kidney and gastrointestinal tract in clinical use. In order to decrease nephrotoxicity of cisplatin, several approaches have been done, such as : (1) Change of administration route and combination therapy with other drugs ; (2) Development of new derivatives : (3) Novel dosage form (design of DDS forms) ; etc. In this paper, preparation of multiple-phase emulsion containing cisplatin and its combination therapy in mouse will be presented. The physicochemical properties and nephrotoxicity of the emulsion were also investigated.
