A Male Case of Systemic Sclerosis with Anti Th/To Antibody

Abstract

We describe a 64-year-old male case of systemic sclerosis with anti-Th/To antibody. He had diffuse skin sclerosis, Raynaud’s phenomenon, pitting scars, a short sublingual frenulum, diffuse pigmentation, and arthralgia. Detailed examination revealed no internal organ involvement. An indirect immunofluorescent test using HEp-2 cells as the substrate showed intense nucleolar staining. Using RNA immunoprecipitation technique, a 7-2 RNA and an 8-2 RNA were precipitated, indicating the presence of anti-Th/To antibody. The clinical features of patients with systemic sclerosis positive for anti-Th/To antibody are discussed.