2002 Volume 112 Issue 10 Pages 1363-1366
Nephropathy is one of the clinically important adverse reactions associated with psoriasis therapy utilizing cyclosporin (CYA). In the present study, kidney biopsies were performed on nine patients with psoriasis and one patient with pyoderma gangrenosum who underwent CYA therapy. Biopsy specimens were analyzed histologically to investigate the relationships between biopsy findings and factors such as CYA dosage. The nine patients with psoriasis (eight men and two women renged in ages from 32 to 72 years), and the one patient with pyoderma gangrenosum was a 32 year-old woman. The duration of CYA therapy ranged from 6 weeks to 11 years (mean : 3.15 years). Glomerular, interstitial and vascular changes were assessed, quantified, and expressed as CYA nephropathy scores. The relationships between CYA nephropathy scores and the following factors were analyzed : age, duration of CYA therapy, mean CYA dosage, total CYA dosage, serum creatinine at the time of the biopsy, and 24-hour creatinine clearance (24hCcr). There was no statistically significant correlation between CYA nephropathy scores and any of the above factors, However a correlation was observed between CYA nephropathy scores and two factors, age and 24hCcr. These findigns demonstrate the need for caution when administering CYA to the elderly and further suggest that 24hCcr can be useful is ascertaining the severity of CYA-induced nephropathy.