Abstract
We report a 54-year-old female with yellow nail syndrome (YNS). The patient first noticed hypertrophic, yellowish nails with slow growth five years ago and then was diagnosed with bronchiectasis two years later. She has sometimes also experienced lymphedma on her face and inferior limbs, so she has the triad sign of YNS. Chronic sinusitis was also associated. As sinusitis has been reported to be accompanied with 20～25% cases of YNS, it should be emphasized that sinusitis is one of the characteristic changes of YNS. Oral therapy with clarithromycin resolved the pleural effusion and sinusitis, and topical therapy with steroids and vitamin D3 improved the nail changes. The present case indicates that macrolide antibiotics should be tried for the treatment of YNS, although there have been no reports showing the therapeutic effects of this medication on YNS.
