A Case Report of Bromoderma

Abstract

A 6-year-old boy visited our department with a one month history of a skin lesion on the face. He had been taking sodium bromide, 1.2 g/day, as an anticonvulsant for three months prior to the onset of the lesion. Physical examination showed erythrmatous, pustular, and nodular lesions with scaly crusts on the face. The serum bromide level was highly increased (150 mg/dl, normal 0 to 0.5 mg/dl). Cultures for bacteria, fungi, and atypical acid-fast bacilli were all negative. A skin biopsy specimen showed epidermal hyperplasia with downward proliferation of the epidermis. In the dermis, there was a dense diffuse infiltrarion of neutrophils accompanied by extensive extravasations of erythrocytes and abscesses within dilated infundibula. The diagnosis of bromoderma was made and sodium bromide was discontinued. The skin lesions healed leaving minimal scarring in two months.