Abstract
Three male patients developed various skin lesions including erythema, red papules, and lichenificated plaques. The lesions spared the large folds of the abdomens. They gradually worsened even though they were treated with topical corticosteroid. Histological findings revealed mild acanthosis in the epidermis and an infiltration predominantly of lymphocytes and eosinophils in the upper dermis. Laboratory examinations revealed hypereosinophilia (Case 1: 24%, Case 2: 29%, Case 3: 17%) without atypical lymphocytes. Based on the clinical and histological findings, they were diagnosed as having papuloerythroderma (Ofuji). We treated all three patients with bath-PUVA therapy. The eruptions disappeared almost completely after the treatments (Case 1: ×16, 41.4 J/cm2; Case 2: ×13, 30.4 J/cm2; Case 3: ×18, 50.5 J/cm2). Hypereosinophilia was improved simultaneously.
