Abstract
Case 1: A 67-year old man presented with a purpuric nodule on his parietal region. The histopathological diagnosis was angiosarcoma. Treatment included local injection of IL-2, tumor excision, and radiation. After these treatments, 180 mg/m2 of paclitaxel was administrated twice at three week intervals, resulting in an decrease in leukocyte count and myalgia/arthralgia. We have been following him in our outpatient clinic. No recurrence or metastasis has been observed in 22 months after the surgery. Case 2: A 72-year old male presented with a 1.5×1.5 cm, dome-shaped nodule on his parietal region. A biopsy specimen revealed angiosarcoma. An additional mass manifested in the left temporal region within two weeks and was diagnosed as a skin metastasis of angiosarcoma by histopathology. Both masses were removed as one. Paclitaxel 60 mg/m2 was administered 12 times at six day intervals concurrent with radiation. He showed no side effects. No recurrence or metastasis has been observed in the 12 months after the surgery. We suggest that multimodal therapy, including paclitaxel, is an effective treatment for angiosarcoma, because the 2 cases mentioned above showed no recurrence or metastasis for at least 12 months.
