2003 Volume 113 Issue 7 Pages 1111-1115
Case 1: A 72-year-old woman had multiple pigmentations on the lips and the fingers and longitudinal streaks. The lesions appeared 10 years earlier and increased in number. Histopathologicaly, melanin pigmentation of basal layer was observed, and some melanophages were scattered in the upper dermis. No abnormality was noticed in functional studies of hormones, endoscopical examination of the lower intestine, or patch tests for 24 metals. Case 2: A 27-year-old woman had some pigmented spots localized on the fingers, lips and mucosa of the left cheek. These pigmentations were first noticed 7 years previously. No other internal or functional disorders were found. These two cases were diagnosed as Laugier-Hunziker-Baran syndrome. In Japan, 37 cases of Laugier-Hunziker-Baran syndrome had been reported. We reviewed the complications, and the treatments of Laugier-Hunziker-Baran syndrome from the literature and our two patients.