Abstract
A 73-year-old man visited our outpatient clinic with active indurated ulcer on his left abdomen. He had been medicated with luteinizing hormone releasing hormone analog for prostate cancer by subcutaneous injections of leuprorelin acetate once a month since August of 2000. In November of 2002, the leuprorelin acetate dosage was changed to a once a three month type drug. Local erythema and induration developed at the injection site after the first injection. Three months later, he developed induration and an ulcer with leakage after the second injection. The biopsied specimen revealed epithelioid cells and giant cells collected together to form a granuloma. For the final diagnosis, we performed an intradermal test with leuprorelin acetate. A positive allergic granulomatous reaction was induced by leuprorelin acetate in this case.
