2004 Volume 114 Issue 4 Pages 813-819
A 25-year-old female first developed fever and purpura in 1994. In October of 1998, hyper-γ-globulinemia, dry mouth, and lymphocyte infiltration in the labial salivary gland were observed, and the patient was diagnosed with Sjögren syndrome. In May of 1999, a subcutaneous induration formed in the right thigh during the course of observation. A biopsy revealed infiltration of atypical lymphocytes in the subcutaneous tissue and fascia, and reconstruction of T cell receptors was also confirmed. The involvement of EB virus was detected by in situ hibridization, and the patient was diagnosed with EB virus-associated subcutaneous T cell lymphoma. Radiotherapy and combination chemotherapy were performed, but the disease did not resolve, and the patient died of immunodeficiency-induced Aspergillus pneumonia two years after the diagnosis.
