2005 Volume 115 Issue 14 Pages 2395-2399
A 40-years-old man with dominant dystrophic epidermolysis bullosa (DDEB) developed a squamous cell carcinoma (SCC) on the left foot. No metastases were observed. The tumor was resected, and the wound was covered with autologous skin grafts. SCC is a frequent complication in the severe and inveterate forms of recessive dystrophic epidermolysis bullosa (RDEB); however, it is only rarely reported in the dominant type. This life-threatening complication should always be kept in mind and a biopsy taken of every chronic, non-healing ulceration and each atypical lesion in all types of epidermolysis bullosa hereditaria. We suggested that it is very important to inform patients and their relatives about this possibility and to teach them to recognize the early characteristics of SCC.
