アトピー性皮膚炎の病勢指標としての血清TARC/CCL17値についての臨床的検討

玉置 邦彦; 佐伯 秀久; 門野 岳史; 佐藤 伸一; 八田 尚人; 長谷川 稔; 白崎 文朗; 島田 由佳; 森田 礼時; 西島 千博; 越後 岳士; 山田 瑞貴; 大石 直人; 中条 園子; 冨田 育代; 平野 貴士; 田中 千洋; 竹原 和彦; 尾藤 利憲; 福永 淳; 堀川 達弥; 梅田 二郎; 森田 博子; 西野 洋; 岡田 明子; 片岡 葉子; 秋永 良也; 占部 和敬; 師井 洋一; 国場 尚志; 今福 信一; 幸田 太; 中原 剛士; 深川 修司; 古江 増隆

doi:10.14924/dermatol.116.27

Original Articles

Serum TARC/CCL 17 Levels as a Disease Marker of Atopic Dermatitis

K. Tamaki, H. Saeki, T. Kadono, S. Sato, N. Hatta, M. Hasegawa, F. Shirasaki, Y. Shimada, R. Morita, C. Nishijima, G. Echigo, M. Yamada, N. Oishi, S. Nakajo, I. Tomita, T. Hirano, C. Tanaka, K. Takehara, T. Bito, A. Fukunaga, T. Horikawa, J. Umeda, H. Morita, H. Nishino, A. Okada, Y. Kataoka, Y. Akinaga, K. Urabe, Y. Moroi, N. Kuniba, S. Imafuku, F. Kohda, T. Nakahara, S. Fukagawa, M. Furue

Author information

K. Tamaki
Department of Dermatology, Fuculty of Medicine, University of Tokyo
H. Saeki
Department of Dermatology, Fuculty of Medicine, University of Tokyo
T. Kadono
Department of Dermatology, Fuculty of Medicine, University of Tokyo
S. Sato
Department of Dermatology, Kanazawa University, School of Medecine
N. Hatta
Department of Dermatology, Kanazawa University, School of Medecine
M. Hasegawa
Department of Dermatology, Kanazawa University, School of Medecine
F. Shirasaki
Department of Dermatology, Kanazawa University, School of Medecine
Y. Shimada
Department of Dermatology, Kanazawa University, School of Medecine
R. Morita
Department of Dermatology, Kanazawa University, School of Medecine
C. Nishijima
Department of Dermatology, Kanazawa University, School of Medecine
G. Echigo
Department of Dermatology, Kanazawa University, School of Medecine
M. Yamada
Department of Dermatology, Kanazawa University, School of Medecine
N. Oishi
Department of Dermatology, Kanazawa University, School of Medecine
S. Nakajo
Department of Dermatology, Kanazawa University, School of Medecine
I. Tomita
Department of Dermatology, Kanazawa University, School of Medecine
T. Hirano
Department of Dermatology, Kanazawa University, School of Medecine
C. Tanaka
Department of Dermatology, Kanazawa University, School of Medecine
K. Takehara
Department of Dermatology, Kanazawa University, School of Medecine
T. Bito
Department of Dermatology, Kobe University, School of Medicine
A. Fukunaga
Department of Dermatology, Kobe University, School of Medicine
T. Horikawa
Department of Dermatology, Kobe University, School of Medicine
J. Umeda
Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases
H. Morita
Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases
H. Nishino
Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases
A. Okada
Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases
Y. Kataoka
Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases
Y. Akinaga
Diagnostics Department, Shionogi & Co., Ltd.
K. Urabe
Department of Dermatology, Kyushu University, School of Medicine
Y. Moroi
Department of Dermatology, Kyushu University, School of Medicine
N. Kuniba
Department of Dermatology, Kyushu University, School of Medicine
S. Imafuku
Department of Dermatology, Kyushu University, School of Medicine
F. Kohda
Department of Dermatology, Kyushu University, School of Medicine
T. Nakahara
Department of Dermatology, Kyushu University, School of Medicine
S. Fukagawa
Department of Dermatology, Kyushu University, School of Medicine
M. Furue
Department of Dermatology, Kyushu University, School of Medicine

Keywords: TARC/CCL17, atopic dermatitis, laboratory marker, disease activity

JOURNAL RESTRICTED ACCESS

2006 Volume 116 Issue 1 Pages 27-39

DOI https://doi.org/10.14924/dermatol.116.27

Details

Abstract

We have previously shown that the serum TARC/CCL17 level reflects the disease activity of atopic dermatitis (AD). In this study we further examined this phenomenon in a larger number of patients and confirmed it. Furthermore, in a longitudinal study of patients with AD, serum TARC/CCL17 levels was examined and compared to other various laboratory markers such as serum LDH, serum IgE, and eosinophil number in peripheral blood. We found that serum TARC/CCL17 levels reflected the disease activity of AD most sensitively than the other laboratory markers. These results indicate that serum TARC/CCL17 levels can be used as a novel laboratory marker to reflect the disease activity of AD.

Corresponding author

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