2008 Volume 118 Issue 8 Pages 1527-1532
During a one-year period from October 2004 to October 2005, we experienced five cases of erythema multiforme type drug eruption that appeared during or after Helicobacter pylori eradication therapy for peptic ulcer. A combination pharmaceutical preparation (brand name: Ransappu) that included lansoprazole, amoxicillin, and clarithromycin was used for H. pylori eradication therapy in four of the five cases. Results of drug lymphocyte stimulation tests were positive in three of the five cases (positive for amoxicillin in two cases and for clarithromycin in one case). One case was positive in a patch test (amoxicillin). One case was negative in both tests but was diagnosed as drug eruption due to H. pylori eradication therapy on the basis of the clinical course.
