Abstract
Three patients (two 71-year-old men and one 57-year-old man) had colorectal cancer with liver metastasis. We attempted several types of chemotherapy after their operations. The next step was therapy with cetuximab, which has an epidermal growth factor receptor inhibitor;it was performed by weekly infusion from October to November of 2008. Two days after the second infusion of cetuximab, acneiform skin lesions appeared on the face and parts of the trunks of all patients. In patient 1, it was possible to see the infiltration of the neutrophils in/out of the hair follicle. All of patients started skin treatment using steroid and antibiotic ointments. Because we did not see any clinical improvement of the acneiform eruption on patient 2 after using steroids and antibiotics, we then treated him with topical tretinoin cream, which was very effective.
