Three Cases of Mucous Membrane Pemphigoid: Usefulness of Various Local Therapies and Amniotic Membrane Transplantation

Abstract

Case 1: A 65-year-old man had lesions on the oral, ocular, and laryngopharyngeal mucous membranes and IgG and IgA autoantibodies reactive with the epidermal side of the basement membrane zone (BMZ). An enzyme-linked immunosorbent assay demonstrated anti-BP180NC16a antibodies. His condition improved with oral prednisolone (PSL) and betamethasone inhalation and eyedrops. Case 2: A 72-year-old woman presented with the oral, ocular, and laryngopharyngeal mucous membranal lesions as well as skin lesions. She had IgG autoantibodies reactive with the dermal side of the BMZ. She was treated with oral PSL and gargling with cyclosporine oral solution. Case 3: A 74-year-old woman had double-headed pterygium and symblepharons in the conjunctiva of both eyes. Her condition improved with oral PSL and amniotic membrane transplantation. Because the incidence of mucous membrane pemphigoid is very low in autoimmune blistering diseases and it is difficult to detect the type of disease or the target antigens, it may not be diagnosed in its early stage. We should keep this disease in mind when we examine patients with mucous membrane lesions.