ロドデノール誘発性脱色素斑症例における二次全国疫学調査結果

日本皮膚科学会　ロドデノール含有化粧品の安全性に関する特別委員会; 鈴木 加余子; 青山 裕美; 伊藤 明子; 鈴木 民夫; 種村 篤; 錦織 千佳子; 伊藤 雅章; 片山 一朗; 大磯 直毅; 深井 和吉; 船坂 陽子; 山下 利春; 松永 佳世子

doi:10.14924/dermatol.124.3125

Committee Report

The Second Epidemiology Report of Rhododenol-induced Leukoderma in Japan Based on a Nationwide Survey

The Special Committee on the Safety of Cosmetics Containing Rhododenol of the Japanese Dermatological Association, Kayoko Suzuki, Yumi Aoyama, Akiko Ito, Tamio Suzuki, Atsushi Tanemura, Chikako Nishigori, Masaaki Ito, Ichiro Katayama, Naoki Oiso, Kazuyoshi Fukai, Yoko Funasaka, Toshiharu Yamashita, Kayoko Matsunaga

Author information

The Special Committee on the Safety of Cosmetics Containing Rhododenol of the Japanese Dermatological Association
Kayoko Suzuki
Department of Dermatology, Kariya Toyota General Hospital
Yumi Aoyama
Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Akiko Ito
Department of Dermatology, Niigata University Medical and Dental Hospital
Tamio Suzuki
Department of Dermatology, Yamagata University Faculty of Medicine
Atsushi Tanemura
Department of Dermatology, Course of Integrated Medicine Graduate School of Medicine, Osaka University
Chikako Nishigori
Division of Dermatology, Department of Internal Related Graduate School of Medicine, Kobe University
Masaaki Ito
Department of Dermatology, Niigata University Graduate School of Medicine and Dental Science
Ichiro Katayama
Department of Dermatology, Course of Integrated Medicine Graduate School of Medicine, Osaka University
Naoki Oiso
Department of Dermatology, Kinki University Faculty of Medicine
Kazuyoshi Fukai
Department of Dermatology, Osaka City University Graduate School of Medicine
Yoko Funasaka
Department of Dermatology, Nippon Medical School
Toshiharu Yamashita
Department of Dermatology, Sapporo Medical University School of Medicine
Kayoko Matsunaga
Department of Dermatology, Fujita Health University School of Medicine

Keywords: Rhododenol, leukoderma, melanogenesis-inhibiting products, ultraviolet light irradiation

JOURNAL RESTRICTED ACCESS

2014 Volume 124 Issue 14 Pages 3125-3142

DOI https://doi.org/10.14924/dermatol.124.3125

Details

Abstract

We report the results of a second nationwide survey aimed at clarifying the clinical course of rhododenol-induced leukoderma. The survey was performed between December 2013 and January 2014, and 1,445 cases were analyzed. With regard to outcome, 72% of the cases were comprehensively evaluated as slightly improved, improved, or cured. In 42% of the cases, we observed hyperpigmentation in the depigmented area or in the surrounding area during the disease course. Among the cases, 56.9% were treated with topical medicaments, oral medicines, or ultraviolet light irradiation, the latter was particularly effective.

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