2017 Volume 127 Issue 12 Pages 2631-2640
We have studied the clinicopathological features of 19 patients with palisaded encapsulated neuroma diagnosed at our institute during the past 10 years. The patients comprised 10 men and 9 women with a mean age of 53.1 years. The mean diameter of the neoplasms was 4.3 mm. Only one lesion was located on the hand, the other lesions arose on the face. Histopathologically, most of the tumors arose in the dermis. Small normal peripheral nerves adjacent to the tumors were observed in 11 lesions. Fifteen of the 16 capsules were EMA antigen positive. These findings indicate the intraneural growth of PENs. An immunohistochemical study using an antibody to neurofilaments revealed that the number of axons varied among these different PENs.