A Case of Linear IgA Bullous Dermatosis Developed after Administration of Vancomycin Hydrochloride

Abstract

An infusion of vancomycin hydrochloride was administered to a 64-year-old woman with pneumonia. Blistering appeared immediately after stopping the infusion, and after re-administration, many blisters appeared in the erythema on the trunk and lower extremity. Anti-DSG1 antibodies, anti-DSG3 antibodies, and anti-BP antibodies were all negative. Histopathological examination revealed blisters and neutrophils, and slight eosinophil infiltration was observed in both the blisters and the superficial layers of the dermis. In direct immunofluorescence, linear IgA deposition was observed at the dermoepidermal junction. She was diagnosed with vancomycin-induced linear IgA bullous dermatosis (LABD). After the vancomycin hydrochloride was discontinued, no vesicle neogenesis was observed, and the erosion became epithelialized. The frequency of use of vancomycin hydrochloride for MRSA infections is expected to increase in the future, so it is necessary to keep this compilation in mind and accumulate further data from future cases.