2020 Volume 130 Issue 2 Pages 233-237
Autoimmune progesterone dermatitis (APD) is a rare hypersensitivity reaction to endogenous progesterone and/or synthetic progestins with multiple clinical manifestations, including erythema, eczema, urticaria, asthma, and anaphylaxis. Although the pathogenesis of APD is poorly understood, protocols for medical management are required particularly for patients interested in fertility and conception. Recently, desensitization has attracted attention. We describe a 25-year-old woman with erythematous plaque and blistering on the distal extremities, which recurred a few days before her menstrual cycle. She was diagnosed with APD by intradermal test. Her symptoms were controlled after prescribing low-dose estrogen-progestin instead of dienogest. The results suggested that low-dose estrogen-progestin may be an effective treatment for APD.
