Clinical Analyses of 22 Cases with Cutaneous Reactions after COVID-19 Vaccination

Abstract

We analyzed the onset time after vaccination, type of cutaneous reactions, and clinical course of 22 patients (4 male and 8 female patients with Moderna vaccine, and 2 male and 8 female patients with Pfizer vaccine) from May to August, 2021. No patient exhibited systemic manifestations. Among the 12 patients who received Moderna vaccine, the onset time in 6 patients with pernio type and in 2 patients with delayed large local reaction type were 6-10 days after vaccination. Two Moderna patients had morbilliform type; one had contact dermatitis without vesicles, and the other urticaria type was after 2-4 days after vaccination. Among the 10 patients who received the Pfizer vaccine, the onset times in the 2 patients with the contact dermatitis type with vesicles, the one patient with pityriasis rosea type, and the one with large local reaction type were 2-8 days after vaccination. The four patients with morbilliform type had variable onset time of 7-22 days. Six patients with morbilliform type, 3 patients with pernio type, and one patient with contact dermatitis type were administered prednisolone, 20-30 mg/day for 10-14 days, and the other patients received anti-histamine drugs and topical corticosteroid treatment. Most of the cutaneous reactions disappeared within 2 weeks after treatments. Although the precise mechanism of cutaneous reactions after COVID-19 vaccination remains unclear, clinical knowledge of such reactions may help the daily practice of healthcare professionals and provide patients with correct information.