2023 Volume 133 Issue 4 Pages 683-687
Multisystem inflammatory syndrome in children (MIS-C) is a new entity disease in which children develop severe cardiovascular disease after SARS-Cov-2 infection. MIS-C presents with a clinical manifestation similar to Kawasaki disease. An 11-year-old boy presented with fever, cardiac dysfunction, and erythema of the trunk and extremities following infection with SARS-Cov-2 three weeks before and was diagnosed with MIS-C. Histopathology of the biopsy showed an erythema multiforme-like pattern. The common skin rashes associated with MIS-C are erythematous papules and erythema multiforme. It has been reported that MIS-C with skin rash exhibits less severe systemic symptoms than MIS-C without skin rash. Kawasaki disease is thought to be caused by molecules produced by pathogenic microorganisms that act on blood vessels and innate immune cells, and MIS-C may be caused by the same mechanism.
