The Exercise Challenge Test Two Cases Led to the Diagnosis of Severe Cholinergic Urticaria

Abstract

In severe cases, cholinergic urticaria can lead to angioedema and anaphylactic shock; a definitive diagnosis and confirmation of its severity are required. We experienced two cases in their 20s of severe cholinergic urticaria with anaphylactic symptoms and confirmed the diagnosis and severity of the disease by the exercize challenge test. Both cases were complicated by atopic dermatitis, and the symptoms were severe at the eczema site. In addition, complications of bronchial asthma and food allergies are also recognized. Definitive diagnosis and control of each disease are important in the diagnosis, treatment, and management of cholinergic urticaria.