Phase III Study of Short Contact Therapy Using Benzoyl Peroxide 5% Gel on Patients with Truncal Acne Vulgaris: Single-arm, Multicenter Study

Abstract

A short contact therapy using benzoyl peroxide 5% gel (BPO-5%) for truncal acne vulgaris led to a reduction in the inflammatory, non-inflammatory and total lesion counts over time. After 12 weeks, the percent of reduction were 73.27%, 60.38% and 65.16%, respectively. Adverse events related to the study drug were observed in 9 of 42 patients, all of which were mild in severity and either recovered or improved, indicating low safety concerns. The efficacy of short contact therapy with BPO-5% has been demonstrated for facial acne in randomized vehicle-controlled double-blind clinical trial, and it is expected to be useful for treating truncal acne vulgaris.