Dokkyo Medical Journal
Online ISSN : 2436-522X
Print ISSN : 2436-5211
Relationship between Cyclical Fluctuations in Renal Disease and Trends in Infectious Diseases
Yuka SatoMakoto AbeAkihiko NagaseTakehiro OhiraYoshiki MurayamaToshihiko IshimitsuAkihiro Tojo
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Supplementary material

2022 Volume 1 Issue 4 Pages 327-336


Background: Infection is an important factor in the development of renal diseases. We investigated the relationship between infection trends and the disease trends in renal biopsies.

Methods: The frequency of renal biopsy diseases in our department over the past 25 years was plotted annually and monthly and compared with the trends of sentinel observation of infectious diseases.

Results: IgA nephropathy increased in a cycle of 3 to 7 years, but its peak gradually decreases. IgA nephropathy showed a weak correlation with group A hemolytic streptococcus and drug-resistant Pseudomonas aeruginosa. On the other hand, in Henoch-Schönlein purpura showed a significant positive correlation with the secular variation of MRSA (r = 0.57, p < 0.01), influenza (r = 0.46, p < 0.05), and genital herpes (r = 0.45, p < 0.05) and condyloma (r = 0.43, p < 0.05). The frequency of ANCA nephritis was significantly correlated with the infection trends of adenovirus pharyngoconjunctival fever (r = 0.48, p < 0.05), hand-foot-mouth disease (r = 0.48, p < 0.05), influenza (r = 0.41, p < 0.05). It also showed a weak correlation with the secular and seasonal trends of group A hemolytic streptococcus. Minimal change nephrotic syndrome increased in a cycle of 4-5 years, and significantly correlated with group A hemolytic streptococcus (r = 0.561, p < 0.01), and the seasonal variation was associated with mycoplasma pneumonia, infectious erythema. Focal segmental glomerulosclerosis showed a significant correlation with the infectious trend of drug-resistant Pseudomonas aeruginosa (r = 0.62, p < 0.01), MRSA (r = 0.53, p < 0.05), Roseola (r = 0.53, p < 0.01), whooping cough (r = 0.42, p < 0.05).

Conclusion: Renal diseases diagnosed by renal biopsy have cyclical variations associated with seasonal and secular variations in infectious disease epidemics.

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© 2022 Dokkyo Medical Society

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