Long-term Effect of Oral Semaglutide on Glycemic Control: An Extended Observational Study over Two Years from Baseline

Abstract

The aim of this study is to investigate the long-term effect of oral semaglutide on glycemic control. The effect on glycemic control of switching from a DPP4 inhibitor to oral semaglutide was examined in an extended period of 2 years from baseline in patients (n = 18) from a previous study. Average HbA1c and GA were significantly decreased by oral semaglutide after 2 years compared to baseline. There were no significant differences in each level among measurement time points of 4 months and 1, 1.5 and 2 years. These results show that the effect of oral semaglutide on glycemic control is maintained over a 2-year period.