2025 Volume 4 Issue 3 Pages 223-227
L-type amino acid transporter 1 (LAT1) is predominantly expressed in a wide variety of cancer cells and plays a pivotal role in providing the amino acids required for cancer growth. LAT1 inhibition has attracted considerable attention as a novel strategy for cancer therapy. However, cancer cells can cope with nutrient deprivation, which reduces the efficacy of LAT1 inhibitor. Herein, we report that phosphoglycerate dehydrogenase (PHGDH) diminishes the antitumor effects of LAT1 inhibition. LAT1 inhibitor upregulated PHGDH in MIA PaCa-2 human pancreatic cancer cells. Furthermore, the antitumor effects of LAT1 inhibitor on MIA PaCa-2 were enhanced when combined with PHGDH inhibitor. Our results suggest novel strategy to improve the efficacy of LAT1 inhibitor in cancer therapy by targeting the nutrient starvation response.
