CYP3A4*18: It is not Rare Allele in Japanese Population

Takehito YAMAMOTO; Nobue NAGAFUCHI; Takeshi OZEKI; Takahiro KUBOTA; Hiroshi ISHIKAWA; Seishi OGAWA; Yasuhiko YAMADA; Hisamaru HIRAI; Tatsuji IGA

doi:10.2133/dmpk.18.267

SNP Communication

CYP3A4^*18: It is not Rare Allele in Japanese Population

Takehito YAMAMOTO, Nobue NAGAFUCHI, Takeshi OZEKI, Takahiro KUBOTA, Hiroshi ISHIKAWA, Seishi OGAWA, Yasuhiko YAMADA, Hisamaru HIRAI, Tatsuji IGA

Author information

Takehito YAMAMOTO
Department of Pharmacy, University of Tokyo Hospital
Nobue NAGAFUCHI
Department of Pharmacy, University of Tokyo Hospital
Takeshi OZEKI
Department of Pharmacy, University of Tokyo Hospital
Takahiro KUBOTA
Department of Pharmacy, University of Tokyo Hospital
Hiroshi ISHIKAWA
Research and Development, Center for Molecular Biology and Cytogenetics, SRL Inc.
Seishi OGAWA
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo
Yasuhiko YAMADA
Department of Pharmacy, University of Tokyo Hospital
Hisamaru HIRAI
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo
Tatsuji IGA
Department of Pharmacy, University of Tokyo Hospital

Keywords: CYP3A4, CYP3A4^*18, allele frequency, Japanese, PCR-RELP

JOURNAL FREE ACCESS

2003 Volume 18 Issue 4 Pages 267-268

DOI https://doi.org/10.2133/dmpk.18.267

Details

Abstract

We sequenced all 13 exons of the CYP3A4 gene derived from 48 Japanese subjects. One subject possess the 20070 T>C mutation in the exon 10 (result in leu293Pro substitution, namely CYP3A4^*18), as heterozygote. Thus, we investigated the frequency of CYP3A4^*18 in 118 Japanese population using polymerase chain reaction-restriction fragment length polymorphism with Msp I and determined that the frequency of the CYP3A4^*18 allele was 1.3%.

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