Drug Metabolism and Pharmacokinetics
Online ISSN : 1880-0920
Print ISSN : 1347-4367
ISSN-L : 1347-4367
SNP Communication
CYP3A4*18: It is not Rare Allele in Japanese Population
Takehito YAMAMOTONobue NAGAFUCHITakeshi OZEKITakahiro KUBOTAHiroshi ISHIKAWASeishi OGAWAYasuhiko YAMADAHisamaru HIRAITatsuji IGA
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2003 Volume 18 Issue 4 Pages 267-268

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Abstract

We sequenced all 13 exons of the CYP3A4 gene derived from 48 Japanese subjects. One subject possess the 20070 T>C mutation in the exon 10 (result in leu293Pro substitution, namely CYP3A4*18), as heterozygote. Thus, we investigated the frequency of CYP3A4*18 in 118 Japanese population using polymerase chain reaction-restriction fragment length polymorphism with Msp I and determined that the frequency of the CYP3A4*18 allele was 1.3%.

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© 2003 by The Japanese Society for the Study of Xenobiotics
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