Two Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2D6 Gene in Japanese Individuals

Aiko EBISAWA; Masahiro HIRATSUKA; Kanako SAKUYAMA; Yumiko KONNO; Takamitsu SASAKI; Michinao MIZUGAKI

doi:10.2133/dmpk.20.294

Drug Metabolism and Pharmacokinetics

Online ISSN : 1880-0920
Print ISSN : 1347-4367
ISSN-L : 1347-4367

SNP Communications

Two Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2D6 Gene in Japanese Individuals

Aiko EBISAWA, Masahiro HIRATSUKA, Kanako SAKUYAMA, Yumiko KONNO, Takamitsu SASAKI, Michinao MIZUGAKI

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Keywords: CYP2D6, genetic polymorphism, Japanese

JOURNAL FREE ACCESS

2005 Volume 20 Issue 4 Pages 294-299

DOI https://doi.org/10.2133/dmpk.20.294

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Abstract

We analyzed all the exons and exon-intron junctions of the CYP2D6 gene from 286 Japanese individuals. We detected two novel single nucleotide polymorphisms (SNPs) 2556C>T in exon 5 (Thr261Ile) and 3835A>C in exon 8 (Lys404Gln). Both these SNPs showed a frequency of 0.002.

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