Absorption and Excretion of OPB 2045 following a Single Oral Administration to Rats
1998 Volume 13 Issue 4 Pages 325-329
Details
1998 Volume 13 Issue 4 Pages 325-329
The absorption and excretion of radioactivity were investigated in Sprague-Dawly rats following a single oral administration of 14C-labeled OPB-2045, and the following results were obtained:
1. Serum levels of radioactivity reached the maximum of 0.09-0.11μg eq. /ml at 30 min in male and female rats after oral administration of 14C-OPB-2045 at 10 mg/kg. The half-life of radioactivity in serum was 5.9-8.6 hr as determined at 2 hr to 24 hr after administration. AUC0-infinite was 0.46-0.59 μg eq.·hr/ml. Radioactivity in blood cells accounted for 7.5-53.1% of total radioactivity in the blood.
2. Urinary and fecal excretion of radioactivity was 1.2-4.6% and 92.1-94.5% of the administered dose, respectively, in rats receiving oral doses of 10 mg/kg. Biliary excretion of radioactivity was 2.9% of the dose within 24 hr after oral administration.
3. No sex difference in absorption or excretion of 14C-OPB-2045 was observed in rats after oral administration of the compound.
