PHARMACOGENOMICS AND DRUG DISCOVERY

Abstract

Gene sequensing and gene expression are of particular significance in pharmacogenomics. Sequencing is used to locate polymorphisms, and monitoring of gene expression can provide clue about the genomic response to disease and treatment. Then, we used gene expression profile analysis to identify therapeutic target genes by studying change of gene expression in animal models of oxidative stress and hypoxia. Oxidative stress and hypoxia are important in the pathogenesis of various diseases. We found novel drug target candidates in oxidative stress and hypoxia through this pharmacogenomic strategy. Our results suggest that the pharmacogenomics have the potential for strategy to define novel drug targets in various diseases.