Development of Evaluation Methods and Computer Softwares for Pharmacokinetic Analysis

Abstract

Some evaluation methods and computer analysis programs on personal computers have been developed for pharmacokinetic analysis. Akaike's Information Criterion (AIC) was introduced to statistically select an optimum model for drug disposition. The moment analysis which has bee been used in chromatography and chemical engineer was applied to the evaluation of absorption, distribution, metabolism and excretion (ADME) of drugs. A pharmacokinetic analysis program based on nonlinear least squares, MULTI, was developed on a personal computer in the early age. We have made other analysis program MULTI (RUNGE) where a pharmacokinetic model is defined as ordinal differential equations, MULTI (FILT) based on a Fast Inverse Laplace Transform (FILT) and MULTI (FEM) based on the Finite Element Method (FEM). MULTI2 (BAYES) based on Bayesian least squares and MULTI (ELS) based on extended least squares were developed for the population pharmacokinetics (PPK).