SCREENING OF PHYSICAL PROPERTIES IN PHARMACEUTICAL DISCOVERY

Abstract

For an entry of a candidate having the suitable oral absorption in a development study, we have developed the methods that were high-throughput for the measurement of pKa, solubility, lipophilicity and permeability. On the development of methods, a platform on analysis operation like 96well format was effective for working some examination methods for evaluating physico-chemical properties systematically. And We have carried out evaluation of their physico-chemical properties with examinations of biological activity simultaneously in the study for lead optimization.