Highly sensitive detection of drugs by HPLC-chemiluminescence reaction cystem

Abstract

The methods of sensitive drug detection by High Performance Liquid Chromatography (HPLC) are reviewed. The following conditions are advantageous for the sensitive detections: application of the columns with small theoretical plates, appropriate flow systems for surpression of peak broadening, and sensitive detection devices such as electrochemical, fluorometrical and luminometrical detection systems for HPLC. Finally, a different kinds of derivatization procedures for drugs for those systems are described.