Foeto-placental Transfer and Excretion into Milk of L-DOPS in Rats

Abstract

¹⁴C-L-DOPS labelled at C-3 position was orally administered to pregnant rats or lactating rats to examine foeto-placental transfer and excretion of radioactivity into the milk.
1. After oral administration of ¹⁴C-L-DOPS (10 mg/kg) to pregnant rats, no radioactivity was detected in the fetus on 13th gestation day, but nearly the same ¹⁴C level as that in the mother was detected on 20th gestation day. The major metabolite in serum of the fetus was 3-OM-DOPS.
When ¹⁴C-L-DOPS (10 mg/kg/day) was orally administered to pregnant rats, from 14th to 20th gestation day, ¹⁴C levels in serum and tissues were found to be substantially similar to those after a single administration.
3. When ¹⁴C-L-DOPS (10 mg/kg) was orally administered to lactating rats, ¹⁴C was transfered from blood to milk mainly as the intact drug.