Abstract
The distribution of 14C-TEI-5103 after single administration (oral: 200 mg/kg, intravenous: 10 mg/kg) and repeated oral administration (200 mg/kg/day) were studied in rats. The passage of radioactivity after oral administration of 14C-TEI-5103 (200 mg/kg) from mothers into the foetuses and the milk were studied in the pregnant and lactating rats, respectively.
After single oral administration of 14C-TEI-5103, the radioactivity was high in the gastric wall and intestine, secondly in the liver and kidney of rats. The radioactivity in the other organs and tissues were lower than that in plasma. After intravenous administration, the radioactivty distributed mainly in the liver, intestine and kidney, but extremely low in the brain and spinal cord.
After both administration, the disappearance of radioactivity in the organs and tissues was rapid.
In case of repeated oral administration for 13 days, the radioactivity in the plasma, reached a plateau at least by the 4 th dosing and in the range of 0.9-1.2 times after single administration. The values of the tissue-to-plasma concentration ratio at 1 hr after repeated dose was almost same as that after a single dose. The accumulation in all tissues was very low.
The passage of radioactivity from mothers into the foetuses and the milk in the pregnant and lactating rats, was extremely low.
