Abstract
Previously, it was reported that guaiacol glycerol ether mononicotinate has an activity of lowering of cholestrerol level in plasma of rabbits and rats.
One of the metabolite, guaiacol glyceric acid ether, [B-(o-methoxyphenoxy) lactic acid] was isolated and also synthesized before.
In order to investigate whether this metabolite has hypocholesteremic action as well as the parent compound, the present work was performed.
First, the methods used for analysis of guaiacol glyceric acid ether are described.
Second, it was found that guaiacol glyceric acid ether, as one of the guaiacol glycerol ether metabolites, increased cholesterol excretion into rat urine especially when a mixitue of the compound and cholesterol was administered to rats.
