1988 Volume 3 Issue 6 Pages 709-715
Disposition and metabolism of [14C]bermoprofen were studied in cynomolgus monkeys after oral administration at the dose of 1 mg/kg.
Plasma level reached the maximum at 2 hr after administration and decreased with apparent half life of 2.1 hr. The extent of gastrointestinal absorption was estimated to be virtually complete based on the ratio of urinary excretion of radioactivity after oral/intravenous administration.
After per oral administration, approximately 76% and 22% of radioactivity were excreted in the urine and feces, respectively. About 38% of radioactivity were excreted in the bile of animals with biliary fistula, whose 63% was reabsorbed: the enterohepatic circulation should be >24% of dose.
Bermoprofen was known to be metabolized mainly by oxidation of methyl group, reduction of carbonyl group and conjugation at propionyl group, and the second biotransformation pathway was found to be predominant in monkeys.
