Studies on the binding of quinidine, disopyramide and lidocaine to purified human α₁-acid glycoprotein

Abstract

The binding of quinidine disopyramide and lidocaine to purified human α₁-acid glycoprotein (AAG-P) was studied using ultrafiltration. These drugs bound to a single class of binding site of AAG-P which was characterized by higher affinity (Kd for quinidine was 7.1×10^-8M, for disopyramide 1.2×10^-6M and for lidocaine 2.0×10^-5M) than that of human serum albumin (HSA). The percent of binding of disopyramide and lidocaine to AAG-P and HSA were mainly related with the concentration of AAG-P.