Abstract
The determination of antidepressants in blood is necessary to obtain the best therapy of patients who are being treated with some of tricyclic or tetracyclic antidepressants. Various methods using high performance liquid chromatography (HPLC) are reported for an analysis of these compounds. The methods involve the manual sample preparation (liquid-liquid, solid-phase extraction columns), semiautomated sample preparation and automated sample preparation. Normal-or reversed-phase columns with functionalities such as C-18, CN, C-1, C-8, and phenyl are used for the separation of antidepressants. This mini-review includes also the determination of selected metabolites.
