1989 Volume 4 Issue 6 Pages 629-635
To detect the effect of activated charcoal suspension that was perfused in the rat peritoneal cavity, the area under the plasma concentration-time curve (AUC) was determined after a loading of benzoic acid (BA) and salicylamide (SAM) simultaneously to the rat by means of an oral administration in vivo or an intestinal perfusion in situ.
Absorption rate constants (ka) of BA and SAM in situ was not affected by charcoal treatment. AUC of BA remained unchanged following charcoal treatment in comparison to untreated group both in situ and in vivo experiments.
The charcoal treatment significantly decreased the AUCc-∞ of SAM in both in situ (59.3%) and in vivo (47.3%) experiments as compared with their corresponding controls. These results showed that about a half of SAM absorbed from the intestinal lumen was initially transported to the peritoneal cavity, and then transported to the circulation system.
