1990 Volume 5 Issue 2 Pages 199-208
The distribution and localization of OPC-7251(zinofloxacin), a new synthetic antibacterial agent, within the skin was examined by measurement of radioactivity and microscopic autoradiography at the application site in guinea pigs, following a percutaneous administration of a single dose (1.4mg/kg).
The distribution of radioactivity in the skin was measured by scintillation counting of skin sections. Radioactivity gradually penetrated into the skin with time, and was localized rather higher in the hair shaft, hair root and sebaceous glands.
The localization of radioactivity in the skin was also determined by microscopic autoradiography.
Consequently, OPC-7251 distributed in hair (modulla of hair, hair roots) and sebaceous glands and is compatible with the treatment of acne vulgaris.
