1990 Volume 5 Issue 3 Pages 307-314
The transfer of 125I-KRN8601 to the fetus or into the milk after a single intravenous administration was investigated in pregnant rats on 19 days of gestation or in lactating rats.
At any time interval after intravenous administration, radioactivity level in the fetus was thirty times lower than that in maternal plasma. It suggests that KRN8601 administered to pregnant rat is not distributed to the fetus.
Radioactive substances of high molecular weights were found in the milk of lactating rats given 125I-KRN8601 intravenously. However none of the radioactive substances were unchanged compounds. Most of the substances are considered to be endogenous high molecular weight compounds into which free iodine produced by degradation of 125I-KRN8601 was incorporated.
