Studies on the Metabolic Fate of Mometasone furoate (MF) (III):Transfer into the Fetus and Milk

Abstract

Foeto-placental transfer and excretion into the milk of radioactivity was studied following subcutaneous administration of ¹⁴C-MF to pregnant or lactating rats at the dose of 0.5mg/kg.
1. On day 13 of gestation, no radioactivity was detected in the fetus based on the whole-body autoradiography.
2. On day 19 of gestation, the highest level of radioactivity, found within the fetus, was observed in the intestinal contents, and almost similar levels as that of mother plasma were observed in the liver and lung as determined by theradioactivity measurement and wholebody autoradiography.
3. Radioactivity level in the milk was nearly two-fold higher than that of plasma at 4hr after administration but it disappeared below detection limit at 72 hr after administration.