1990 Volume 5 Issue 6 Pages 845-851
Distribution of radioactivity in the stomach with acetic acid-induced ulcer was studied after oral administrations of 14C-KT1-32 to male rats.
1. The significantly high radioactivity was found in the site of the gastric ulcer at 6, 12 and 24hr after administration.
2. Radioactivity in normal mucosa was significantly higher than that in muscular layer at 1hr, but there were no significant differences between these tissues at 3, 6, 12 and 24hr.
3. Microautoradiography indicated that the density gradient of silver grains was found from the lumen to the muscular layer in glandular stomach at 3hr after administration. These results suggested that 14C-KT1-32 was located selectively in the lesion of the gastric ulcer induced with acetic acid for long period and penetrated throught the lumen to the muscular after oral administration.